Allerjin

Allerjin may be available in the countries listed below.

Ingredient matches for Allerjin

Diphenhydramine

Diphenhydramine hydrochloride (a derivative of Diphenhydramine) is reported as an ingredient of Allerjin in the following countries:

• Turkey

International Drug Name Search

CefpoLEK

CefpoLEK may be available in the countries listed below.

Ingredient matches for CefpoLEK

Cefpodoxime

Cefpodoxime is reported as an ingredient of CefpoLEK in the following countries:

• Poland

International Drug Name Search

Ceflonic

Ceflonic may be available in the countries listed below.

Ingredient matches for Ceflonic

Cefoperazone

Cefoperazone sodium salt (a derivative of Cefoperazone) is reported as an ingredient of Ceflonic in the following countries:

• Japan

Sulbactam

Sulbactam sodium salt (a derivative of Sulbactam) is reported as an ingredient of Ceflonic in the following countries:

• Japan

International Drug Name Search

Psibeter

Psibeter may be available in the countries listed below.

Ingredient matches for Psibeter

Buspirone

Buspirone hydrochloride (a derivative of Buspirone) is reported as an ingredient of Psibeter in the following countries:

• Portugal

International Drug Name Search

Fortabs

Generic Name: butalbital and aspirin combination (Oral route)

Commonly used brand name(s)

In the U.S.

• Fiorinal


• Fortabs


• Laniroif

Available Dosage Forms:

• Tablet


• Capsule

Uses For Fortabs

Butalbital and aspirin combination is a pain reliever and relaxant. It is used to treat tension headaches. Butalbital belongs to the group of medicines called barbiturates. Barbiturates act in the central nervous system (CNS) to produce their effects.

When you use butalbital for a long time, your body may get used to it so that larger amounts are needed to produce the same effects. This is called tolerance to the medicine. Also, butalbital may become habit-forming (causing mental or physical dependence) when it is used for a long time or in large doses. Physical dependence may lead to withdrawal side effects when you stop taking the medicine. In patients who get headaches, the first symptom of withdrawal may be new (rebound) headaches.

Some of these medicines also contain caffeine. Caffeine may help to relieve headaches. However, caffeine can also cause physical dependence when it is used for a long time. This may lead to withdrawal (rebound) headaches when you stop taking it.

Butalbital and aspirin combination is sometimes also used for other kinds of headaches or other kinds of pain, as determined by your doctor.

These medicines are available only with your doctor's prescription.

Before Using Fortabs

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

For butalbital:

• Although barbiturates such as butalbital often cause drowsiness, some children become excited after taking them.

For aspirin:

• Do not give a medicine containing aspirin to a child with fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing its use with your child's doctor. This is very important because aspirin may cause a serious illness called Reye's syndrome in children with fever caused by a virus infection, especially flu or chickenpox. Children who do not have a virus infection may also be more sensitive to the effects of aspirin, especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating. This may increase the chance of side effects during treatment.

For caffeine:

• There is no specific information comparing use of caffeine in children up to 12 years of age with use in other age groups. However, caffeine is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

For butalbital:

• Confusion, depression, or excitement may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of butalbital.

For aspirin:

• Elderly patients are more sensitive than younger adults to the effects of aspirin. This may increase the chance of side effects during treatment.

For caffeine:

• Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of caffeine in the elderly with use in other age groups.

Pregnancy

For butalbital:

• Barbiturates such as butalbital have been shown to increase the chance of birth defects in humans. Also, one study in humans has suggested that barbiturates taken during pregnancy may increase the chance of brain tumors in the baby. Butalbital may cause breathing problems in the newborn baby if taken just before or during delivery.

For aspirin:

• Although studies in humans have not shown that aspirin causes birth defects, it has caused birth defects in animal studies.


• Do not take aspirin during the last 3 months of pregnancy unless it has been ordered by your doctor. Some reports have suggested that use of aspirin late in pregnancy may cause a decrease in the newborn's weight and possible death of the fetus or newborn baby. However, the mothers in these reports had been taking much larger amounts of aspirin than are usually recommended. Studies of mothers taking aspirin in the doses that are usually recommended did not show these unwanted effects.


• There is a chance that regular use of aspirin late in pregnancy may cause unwanted effects on the heart or blood flow in the fetus or in the newborn baby. Also, use of aspirin during the last 2 weeks of pregnancy may cause bleeding problems in the fetus before or during delivery or in the newborn baby. In addition, too much use of aspirin during the last 3 months of pregnancy may increase the length of pregnancy, prolong labor, cause other problems during delivery, or cause severe bleeding in the mother before, during, or after delivery.

For caffeine:

• Studies in humans have not shown that caffeine causes birth defects. However, use of large amounts of caffeine during pregnancy may cause problems with the heart rhythm and the growth of the fetus. Also, studies in animals have shown that caffeine causes birth defects when given in very large doses (amounts equal to the amount in 12 to 24 cups of coffee a day).

Breast Feeding

Although this combination medicine has not been reported to cause problems, the chance always exists, especially if the medicine is taken for a long time or in large amounts.

For butalbital:

• Barbiturates such as butalbital pass into the breast milk and may cause drowsiness, unusually slow heartbeat, shortness of breath, or troubled breathing in nursing babies.

For aspirin:

• Aspirin passes into the breast milk. However, taking aspirin in the amounts present in these combination medicines has not been reported to cause problems in nursing babies.

For caffeine:

• The caffeine in some of these combination medicines passes into the breast milk in small amounts. Taking caffeine in the amounts present in these medicines has not been reported to cause problems in nursing babies. However, studies have shown that nursing babies may appear jittery and have trouble in sleeping when their mothers drink large amounts of caffeine-containing beverages. Therefore, breast-feeding mothers who use caffeine-containing medicines should probably limit the amount of caffeine they take in from other medicines or from beverages.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

• Influenza Virus Vaccine, Live


• Ketorolac

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acenocoumarol


• Adinazolam


• Alfentanil


• Alprazolam


• Alteplase, Recombinant


• Amobarbital


• Anileridine


• Anisindione


• Aprobarbital


• Beta Glucan


• Bromazepam


• Brotizolam


• Butabarbital


• Butalbital


• Carisoprodol


• Chloral Hydrate


• Chlordiazepoxide


• Chlorzoxazone


• Cilostazol


• Citalopram


• Clobazam


• Clonazepam


• Clorazepate


• Clovoxamine


• Codeine


• Dabigatran Etexilate


• Dantrolene


• Desirudin


• Desvenlafaxine


• Diazepam


• Dicumarol


• Duloxetine


• Eptifibatide


• Escitalopram


• Estazolam


• Ethchlorvynol


• Femoxetine


• Fentanyl


• Flesinoxan


• Flunitrazepam


• Fluoxetine


• Flurazepam


• Fluvoxamine


• Ginkgo


• Halazepam


• Heparin


• Hydrocodone


• Hydromorphone


• Ketazolam


• Ketoprofen


• Levorphanol


• Lorazepam


• Lormetazepam


• Medazepam


• Meperidine


• Mephenesin


• Mephobarbital


• Meprobamate


• Metaxalone


• Methocarbamol


• Methohexital


• Methotrexate


• Midazolam


• Milnacipran


• Morphine


• Morphine Sulfate Liposome


• Naproxen


• Nefazodone


• Nitrazepam


• Nordazepam


• Oxazepam


• Oxycodone


• Oxymorphone


• Paroxetine


• Pentobarbital


• Phenindione


• Phenobarbital


• Phenprocoumon


• Prazepam


• Primidone


• Propoxyphene


• Quazepam


• Quetiapine


• Remifentanil


• Reteplase, Recombinant


• Rivaroxaban


• Secobarbital


• Sertraline


• Sodium Oxybate


• Sufentanil


• Temazepam


• Thiopental


• Ticlopidine


• Triazolam


• Varicella Virus Vaccine


• Venlafaxine


• Vilazodone


• Warfarin


• Zimeldine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse (or history of) or


• Drug abuse or dependence (or history of)—Dependence on butalbital may develop.

• Asthma, especially if occurring together with other allergies and nasal polyps (or history of), or


• Emphysema or other chronic lung disease or


• Hyperactivity (in children) or


• Kidney disease or


• Liver disease—The chance of serious side effects may be increased.

• Diabetes mellitus (sugar diabetes) or


• Mental depression or


• Overactive thyroid or


• Porphyria (or history of)—Butalbital may make these conditions worse.

• Gout—Aspirin can make this condition worse and can also lessen the effects of some medicines used to treat gout.

• Heart disease (severe)—The caffeine in some of these combination medicines can make some kinds of heart disease worse.

• Hemophilia or other bleeding problems or


• Vitamin K deficiency—Aspirin increases the chance of serious bleeding.

• Stomach ulcer, especially with a history of bleeding, or other stomach problems—Aspirin can make your condition worse.

Proper Use of butalbital and aspirin combination

This section provides information on the proper use of a number of products that contain butalbital and aspirin combination. It may not be specific to Fortabs. Please read with care.

Take this medicine with food or a full glass (8 ounces) of water to lessen stomach irritation.

Do not take this medicine if it has a strong vinegar-like odor. This odor means the aspirin in it is breaking down. If you have any questions about this, check with your health care professional.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If butalbital and aspirin combination is taken regularly (for example, every day), it may become habit-forming (causing mental or physical dependence). The caffeine in some butalbital and aspirin combinations can also increase the chance of dependence. Dependence is especially likely to occur in patients who take this medicine to relieve frequent headaches. Taking too much of this combination medicine can also lead to stomach problems or to other medical problems.

This medicine will relieve a headache best if you take it as soon as the headache begins. If you get warning signs of a migraine, take this medicine as soon as you are sure that the migraine is coming. This may even stop the headache pain from occurring. Lying down in a quiet, dark room for a while after taking the medicine also helps to relieve headaches.

People who get a lot of headaches may need to take a different medicine to help prevent headaches. It is important that you follow your doctor's directions about taking the other medicine, even if your headaches continue to occur. Headache-preventing medicines may take several weeks to start working. Even after they do start working, your headaches may not go away completely. However, your headaches should occur less often, and they should be less severe and easier to relieve than before. This will reduce the amount of headache relievers that you need. If you do not notice any improvement after several weeks of headache-preventing treatment, check with your doctor.

Dosing

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For butalbital and aspirin combination


• For oral dosage form (tablets):
  
  • For tension headaches:
    
    • Adults—One tablet every four hours as needed. You should not take more than six tablets a day.
    
    
    • Children—Dose must be determined by your doctor.
    
    
  
  

• For butalbital, aspirin, and caffeine combination


• For oral dosage forms (capsules or tablets):
  
  • For tension headaches:
    
    • Adults—One or 2 capsules or tablets every four hours as needed. You should not take more than six capsules or tablets a day.
    
    
    • Children—Dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Fortabs

Check with your doctor:

• If the medicine stops working as well as it did when you first started using it. This may mean that you are in danger of becoming dependent on the medicine. Do not try to get better pain relief by increasing the dose.


• If you are having headaches more often than you did before you started using this medicine. This is especially important if a new headache occurs within 1 day after you took your last dose of headache medicine, headaches begin to occur every day, or a headache continues for several days in a row. This may mean that you are dependent on the headache medicine. Continuing to take this medicine will cause even more headaches later on. Your doctor can give you advice on how to relieve the headaches.

Check the labels of all nonprescription (over-the-counter [OTC]) and prescription medicines you now take. If any contain a barbiturate, aspirin, or other salicylates, including diflunisal, check with your health care professional. Taking them together with this medicine may cause an overdose.

The butalbital in this medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; other barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Also, stomach problems may be more likely to occur if you drink alcoholic beverages while you are taking aspirin. Therefore, do not drink alcoholic beverages, and check with your doctor before taking any of the medicines listed above, while you are using this medicine.

This medicine may cause some people to become drowsy, dizzy, or lightheaded. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert and clearheaded.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine. Serious side effects may occur if your medical doctor or dentist gives you certain other medicines without knowing that you have taken butalbital.

Do not take this medicine for 5 days before any planned surgery, including dental surgery, unless otherwise directed by your medical doctor or dentist. Taking aspirin during this time may cause bleeding problems.

Before you have any medical tests, tell the person in charge that you are taking this medicine. Caffeine (present in some butalbital and aspirin combinations) interferes with the results of certain tests that use dipyridamole (e.g., Persantine) to help show how well blood is flowing to your heart. Caffeine should not be taken for 8 to 12 hours before the test. The results of some other tests may also be affected by butalbital and aspirin combinations.

If you have been taking large amounts of this medicine, or if you have been taking it regularly for several weeks or more, do not suddenly stop using it without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely, to lessen the chance of withdrawal side effects.

If you think you or anyone else may have taken an overdose of this medicine, get emergency help at once. Taking an overdose of this medicine or taking alcohol or CNS depressants with this medicine may lead to unconsciousness or death. Symptoms of overdose of this medicine include convulsions (seizures); hearing loss; confusion; ringing or buzzing in the ears; severe excitement, nervousness, or restlessness; severe dizziness; severe drowsiness; shortness of breath or troubled breathing; and severe weakness.

Fortabs Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common or rare - may mean that a serious allergic reaction is occurring

• Bluish discoloration or flushing or redness of skin (occurring together with other effects listed in this section)


• coughing, shortness of breath, troubled breathing, tightness in chest, or wheezing


• difficulty in swallowing


• dizziness or feeling faint (severe)


• hive-like swellings (large) on eyelids, face, lips, or tongue


• skin rash, itching, or hives


• stuffy nose (occurring together with other effects listed in this section)

Rare

• Bleeding or crusting sores on lips


• chest pain


• fever with or without chills


• red, thickened, or scaly skin


• sores, ulcers, or white spots in mouth (painful)


• sore throat (unexplained)


• tenderness, burning, or peeling of skin

Symptoms of overdose

• Anxiety, confusion, excitement, irritability, nervousness, restlessness, or trouble in sleeping (severe, especially with products containing caffeine)


• convulsions (seizures, with products containing caffeine)


• diarrhea (severe or continuing)


• dizziness, lightheadedness, drowsiness, or weakness (severe)


• frequent urination (for products containing caffeine)


• hallucinations (seeing, hearing, or feeling things that are not there)


• increased sensitivity to touch or pain (for products containing caffeine)


• increased thirst


• muscle trembling or twitching (for products containing caffeine)


• nausea or vomiting (severe or continuing), sometimes with blood


• ringing or buzzing in ears (continuing) or hearing loss


• seeing flashes of "zig-zag" lights (for products containing caffeine)


• slow, fast, or irregular heartbeat


• slow, fast, irregular, or troubled breathing


• slurred speech


• staggering


• stomach pain (severe)


• uncontrollable flapping movements of the hands, especially in elderly patients


• unusual movements of the eyes


• vision problems

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

• Bloody or black, tarry stools


• bloody urine


• confusion or mental depression


• muscle cramps or pain


• pinpoint red spots on skin


• swollen or painful glands


• unusual bleeding or bruising


• unusual excitement (mild)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Bloated or "gassy" feeling


• dizziness or lightheadedness (mild)


• drowsiness (mild)


• heartburn or indigestion


• nausea, vomiting, or stomach pain (occurring without other symptoms of overdose)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

Simcor

Pronunciation: SIM-va-STAT-in/NYE-a-sin
Generic Name: Simvastatin/Niacin
Brand Name: Simcor

Simcor is used for:

Lowering high cholesterol and triglycerides in certain patients. It also increases high-density lipoprotein (HDL, "good") cholesterol levels. It is used along with an appropriate diet. It may also be used for other conditions as determined by your doctor.

Simcor is an HMG-CoA reductase inhibitor and niacin combination. The HMG-CoA reductase inhibitor works by reducing the production of certain fatty substances in the body, including cholesterol. The niacin works by reducing low-density lipoprotein (LDL, "bad") cholesterol and triglycerides and increasing HDL cholesterol.

Do NOT use Simcor if:

• you are allergic to any ingredient in Simcor


• you are pregnant, may become pregnant, or are breast-feeding


• you have liver problems, unexplained abnormal liver function tests, active peptic ulcer disease, or certain types of active bleeding (arterial bleeding)


• you take amiodarone, cyclosporine, danazol, diltiazem, fibrates (eg, clofibrate, fenofibrate, gemfibrozil), a hepatitis C virus (HCV) protease inhibitor (eg, boceprevir, telaprevir), an HIV protease inhibitor (eg, lopinavir, nelfinavir, ritonavir), itraconazole, ketoconazole, certain macrolide antibiotics (eg, clarithromycin, erythromycin), mibefradil, nefazodone, posaconazole, telithromycin, or verapamil


• you take or have taken conivaptan within the past 7 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Simcor:

Some medical conditions may interact with Simcor. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are able to become pregnant


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of liver problems; abnormal liver function tests; yellowing of the skin or eyes; kidney problems; diabetes; underactive thyroid; electrolyte, endocrine, or metabolism problems; blood or bleeding problems (eg, low blood platelet levels); low blood pressure; gout; muscle pain or weakness; seizures; or ulcers


• if you are dehydrated, have a severe infection or a recent serious injury, or are very ill


• if you drink large amounts of alcohol or if you have a history of alcohol abuse


• if you are scheduled to have surgery or if you have received an organ transplant


• if you have taken or are taking immediate-release (short-acting) niacin, another product that contains niacin, or vitamins or other supplements that contain niacin or nicotinamide


• if you have not previously taken simvastatin or a long-acting niacin. Simcor should only be used in patients who already take simvastatin or long-acting niacin

Some MEDICINES MAY INTERACT with Simcor. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amiodarone, amlodipine, azole antifungals (eg, itraconazole, ketoconazole, posaconazole, voriconazole), colchicine, conivaptan, cyclosporine , danazol, daptomycin, delavirdine, diltiazem, dronedarone, fibrates (eg, clofibrate, fenofibrate, gemfibrozil), fusidic acid, HCV protease inhibitors (eg, boceprevir, telaprevir), HIV protease inhibitors (eg, lopinavir, nelfinavir, ritonavir), imatinib, ketolides (eg, telithromycin), macrolide antibiotics (eg, clarithromycin, erythromycin), mibefradil , nefazodone, ranolazine, streptogramins (eg, dalfopristin, quinupristin), or verapamil because the risk of myopathy (eg, muscle pain, tenderness, weakness) may be increased


• Bosentan, carbamazepine, efavirenz, rifamycins (eg, rifampin), or St. John's wort because they may decrease Simcor's effectiveness


• Anticoagulants (eg, warfarin), digoxin, or macrolide immunosuppressants (eg, tacrolimus) because the risk of their side effects may be increased by Simcor


• Certain medicines for high blood pressure (eg, clonidine, prazosin) because the risk of a sudden drop in blood pressure when sitting or standing up, which may cause dizziness or light-headedness, may be increased by Simcor

This may not be a complete list of all interactions that may occur. Ask your health care provider if Simcor may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Simcor:

Use Simcor as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Simcor by mouth at bedtime with a low-fat snack (eg, low-fat yogurt, banana, crackers with a glass of low-fat milk), unless your doctor tells you otherwise. Taking Simcor with a low-fat snack may reduce flushing and stomach upset from Simcor. Do not take Simcor on an empty stomach.


• Do not drink alcohol or hot drinks, or eat spicy foods around the time you take Simcor. This may also help to reduce the risk of flushing.


• Swallow Simcor whole. Do not break, crush, or chew before swallowing.


• Eating grapefruit or drinking grapefruit juice may increase the amount of Simcor in your blood, which may increase your risk of serious side effects. The risk may be greater with large amounts of grapefruit or grapefruit juice. Avoid large amounts of grapefruit or grapefruit juice (eg, more than 1 quart daily) while you are using Simcor. Talk with your doctor or pharmacist if you have questions about including grapefruit or grapefruit juice in your diet while you are taking Simcor.


• If you take cholestyramine or colestipol, take Simcor at least 4 to 6 hours after you take cholestyramine or colestipol.


• Take Simcor on a regular schedule to get the most benefit from it. Taking Simcor at the same time each day will help you remember to take it.


• Continue to take Simcor even if you feel well. Do not miss any doses.


• If you miss a dose of Simcor, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss taking Simcor for several days in a row, contact your doctor before you start to take it again. Your dose may need to be adjusted.

Ask your health care provider any questions you may have about how to use Simcor.

Important safety information:

• Simcor may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Simcor with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Simcor may cause liver problems. Rarely, severe and sometimes fatal liver failure has been reported in patients taking Simcor. Your risk of developing liver problems may be greater if you drink alcohol daily or in large amounts with Simcor, or if you have a history of liver problems. Check with your doctor before drinking alcohol while you are taking Simcor. Tell your doctor right away if you experience symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; severe or persistent nausea, loss of appetite, or stomach pain; unusual tiredness).


• For best results, Simcor should be used along with exercise, a low-cholesterol/low-fat diet, and a weight loss program if you are overweight. Follow the diet and exercise program given to you by your health care provider.


• Do NOT take more than the recommended dose without checking with your doctor.


• Tell your doctor or dentist that you take Simcor before you receive any medical or dental care, emergency care, or surgery. Simcor may need to be stopped for a few days before certain types of surgery.


• Flushing may occur with Simcor and can last for several hours. Take Simcor at bedtime so that flushing will occur during sleep, unless your doctor tells you otherwise. If you are awakened by flushing at night, get up slowly, especially if you feel dizzy or faint, or if you are taking blood pressure medicines. Taking aspirin 30 minutes before you take Simcor may lessen flushing. Talk with your doctor to see if you should take aspirin before you take Simcor or if flushing becomes bothersome.


• Muscle problems (myopathy) may occur with Simcor. The risk of muscle problems may be greater in people who take higher doses of Simcor, in people older than 64 years old, in females, or in people who have kidney problems or low thyroid function. It may also be greater in those who take it with certain other medicines (eg, niacin), especially in Chinese patients. Tell your doctor right away if you notice any unexplained muscle pain, tenderness, or weakness, especially if you also have a fever or general body discomfort.


• Certain conditions may increase your risk of serious muscle problems. These may include dehydration; low blood pressure; major surgery or injury; severe infection; uncontrolled seizures; or serious metabolism, endocrine, or electrolyte problems. Contact your doctor right away if you develop one of these conditions.


• Diabetes patients - Simcor may increase your blood sugar levels. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Rarely, changes to the skin, hair, and nails (eg, discoloration, dryness, hair loss) may occur. Check with your doctor if these effects become bothersome or cause you concern.


• Simcor may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.


• Simcor has niacin in it. Before you start any new medicine, check the label to see if it has niacin or nicotinamide in it too. This includes vitamins and other supplements. If it does or you are not sure, check with your doctor or pharmacist.


• Women who are able to become pregnant should use effective birth control while taking Simcor. Check with your doctor if you have questions about using birth control.


• Lab tests, including liver function, blood sugar, blood cholesterol, and creatine phosphokinase (CPK) blood levels, may be performed while you use Simcor. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Simcor with caution in the ELDERLY; they may be more sensitive to its effects, especially muscle problems.


• Simcor should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Do not take Simcor if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Simcor is found in breast milk. Do not breast-feed while taking Simcor.

Possible side effects of Simcor:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; diarrhea; dizziness; flushing (eg, itching, redness, tingling, warmth); headache; nausea; runny or stuffy nose; stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); burning, numbness, or persistent tingling; change in the amount of urine produced; dark or red-colored urine; dark, tarry, or bloody stools; decreased sexual ability; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; increased sweating; joint pain; loss of appetite; memory problems; muscle pain, tenderness, or weakness (with or without fever and fatigue); pale stools; red, swollen, blistered, or peeling skin; severe or persistent dizziness or light-headedness; severe or persistent nausea or stomach or back pain; shortness of breath; swelling of the hands, legs, or feet; trouble sleeping; unusual bruising or bleeding; unusual tiredness or weakness; vision changes; vomiting; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Simcor side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Simcor:

Store Simcor at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Simcor out of the reach of children and away from pets.

General information:

• If you have any questions about Simcor, please talk with your doctor, pharmacist, or other health care provider.


• Simcor is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Simcor. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Simcor resources

• Simcor Side Effects (in more detail)
• Simcor Use in Pregnancy & Breastfeeding
• Simcor Drug Interactions
• Simcor Support Group
• 8 Reviews for Simcor - Add your own review/rating

• Simcor Prescribing Information (FDA)


• Simcor Advanced Consumer (Micromedex) - Includes Dosage Information


• Simcor Consumer Overview

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Tinidazole

In the US, Tinidazole (tinidazole systemic) is a member of the drug class amebicides and is used to treat Amebiasis, Bacterial Vaginitis, Giardiasis and Trichomoniasis.

US matches:

• Tinidazole

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

J01XD02,P01AB02

CAS registry number (Chemical Abstracts Service)

0019387-91-8

Chemical Formula

C8-H13-N3-O4-S

Molecular Weight

247

Therapeutic Category

Antiprotozoal agent: Trichomonacidal

Chemical Name

1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-

Foreign Names

• Tinidazolum (Latin)
• Tinidazol (German)
• Tinidazole (French)
• Tinidazol (Spanish)

Generic Names

• Tinidazole (OS: BAN, DCF, JAN, USAN)
• Tinidazolo (OS: DCIT)
• CP 12574 (IS)
• Tinidazol (PH: Ph. Eur. 6)
• Tinidazole (PH: BP 2010, JP XIV, USP 32, Ph. Eur. 6)
• Tinidazolum (PH: Ph. Eur. 6)

Brand Names

• Afumix (Tinidazole and Fluconazole)
  Senosiain, Peru



• Alcip-TZ (Tinidazole and Ciprofloxacin)
  Allenge, India



• Amebamagma
  Wyeth, India



• Amibiol
  Etyc, Colombia



• Amplium
  Farmasa, Brazil



• Amtiba
  Cadila Health Care, Ethiopia



• Enidazol
  East India, India



• Estovyn-T
  Grossman, Mexico



• Famidal (Tinidazole and Miconazole)
  ABL, Peru



• Fasigin-N (Tinidazole and Nystatin)
  Pfizer, Italy



• Fasigyn
  Pfizer, United Arab Emirates; Pfizer, Argentina; Pfizer, Australia; Pfizer, Belgium; Pfizer, Bahrain; Pfizer, Belize; Pfizer, Chile; Pfizer, Colombia; Pfizer, Costa Rica; Pfizer, Cyprus; Pfizer, Dominican Republic; Pfizer, Ecuador; Pfizer, Egypt; Pfizer, Egypt; Pfizer, United Kingdom; Pfizer, Georgia; Pfizer, Greece; Pfizer, Guatemala; Pfizer, Guyana; Pfizer, Hong Kong; Pfizer, Honduras; Pfizer, Israel; Pfizer, India; Pfizer, Jordan; Pfizer, Kenya; Pfizer, Kuwait; Pfizer, Lebanon; Pfizer, Sri Lanka; Pfizer, Luxembourg; Pfizer, Malawi; Pfizer, Mexico; Pfizer, Nigeria; Pfizer, Nicaragua; Pfizer, Oman; Pfizer, Panama; Pfizer, Peru; Pfizer, Portugal; Pfizer, Romania; Pfizer, Saudi Arabia; Pfizer, Sudan; Pfizer, Sweden; Pfizer, Singapore; Pfizer, El Salvador; Pfizer, Thailand; Pfizer, Uganda; Pfizer, Venezuela; Pfizer, South Africa; Pfizer Pharma, Ethiopia



• Fasigyne
  Pfizer, Burkina Faso; Pfizer, Benin; Pfizer, Central African Republic; Pfizer, Congo; Pfizer, Cote D'ivoire; Pfizer, Cameroon; Pfizer, Gabon; Pfizer, Guinea; Pfizer, Madagascar; Pfizer, Mali; Pfizer, Mauritania; Pfizer, Mauritius; Pfizer, Niger; Pfizer, Senegal; Pfizer, Chad; Pfizer, Togo; Pfizer, Tunisia; Pfizer, Vietnam; Pfizer, Zaire; Teofarma, France



• Ginedazol (Tinidazole and Miconazole)
  Medco, Peru



• Gynormal
  Andromaco, Argentina



• Gynoval (Tinidazole and Miconazole)
  Markos, Peru



• Gynozol (Tinidazole and Ketoconazole)
  Medifarma, Peru



• Haisigyn
  Fuji Yakuhin, Japan



• Ladylen
  Mertens, Argentina



• Medivel (Tinidazole and Miconazole)
  Medifarma, Peru



• Midazole
  Micro Labs, Myanmar



• Pangamil
  Biotech, Venezuela



• Pletil
  Pfizer, Brazil



• Protocide
  Unipharm, Israel



• Protogyn
  Hayat, United Arab Emirates; Hayat, Bahrain; Hayat, Iraq; Hayat, Jordan; Hayat, Lebanon; Hayat, Libya; Hayat, Qatar; Hayat, Saudi Arabia; Hayat, Sudan; Hayat, Yemen; Renata, Bangladesh



• Protozole
  Medical Union Pharmaceuticals, Ethiopia



• Simplotan
  Pfizer, Australia



• Sporinex
  Medochemie, Oman



• Timerol
  Remedica, Cyprus



• Tindamax
  Mission, United States; Presutti, United States



• Tiniba
  Cadila, Ghana; Cadila, Kenya; Cadila, Malawi; Cadila, Nigeria; Cadila, Sudan; Cadila, Tanzania; Cadila, Uganda; Cadila, Zambia; Cadila Health Care, Ethiopia; Zydus, Latvia; Zydus, Russian Federation; Zydus Cadila, India; Zydus Cadila, Myanmar



• Tinidafyl
  Jagson Pal, India



• Tinidal
  Farmacoop, Colombia



• Tinidan
  ECU, Ecuador



• Tinidazol Actavis
  Balkanpharma, Bulgaria



• Tinidazol Best
  Best, Colombia



• Tinidazol Domesco
  Domesco, Vietnam



• Tinidazol Ecar
  Ecar, Colombia



• Tinidazol Genfar
  Genfar, Colombia; Genfar, Ecuador; Genfar, Peru



• Tinidazol L.CH.
  Chile, Chile



• Tinidazol La Santé
  La Santé, Colombia



• Tinidazol Lch
  Ivax, Peru



• Tinidazol MK
  Bonima, Costa Rica; Bonima, Dominican Republic; Bonima, Guatemala; Bonima, Honduras; Bonima, Nicaragua; Bonima, Panama; Bonima, El Salvador; McKesson, Ecuador; MK, Colombia



• Tinidazol Polpharma
  Polpharma, Latvia; Polpharma, Poland



• Tinidazol
  Actavis, Georgia; Actavis, Lithuania; AZ Pharma, Colombia; Blaskov, Colombia; Ecuaquímica, Ecuador; Elter - Medicamentos Genéricos, Venezuela; Ivax, Peru; La Sante, Peru; Medicalex, Colombia; Mintlab, Chile; Pentacoop, Colombia; Pentacoop, Peru; PlusAndex, Venezuela; Polpharma, Georgia; Polpharma, Lithuania; Sicomed, Georgia; Synthesis, Colombia



• Tinidazole
  Flamingo Pharmacueticals, Ethiopia; Limasole Industrial Estate, Ethiopia; Polpharma, Hungary; Remedica, Ethiopia; Unique, Russian Federation; Yung Shin, Taiwan



• Tinidazole-Akri
  Akrihin, Russian Federation



• Tinidazolum
  Polpharma, Poland



• Tinidral
  Infaca, Dominican Republic



• Tinigen
  Genamerica, Ecuador



• Tinizol
  Infomed, Romania; Zentiva, Romania



• Tiprogyn
  Helcor, Romania



• Tizol
  Farqui, Dominican Republic



• Triagil
  Galenika, Serbia



• Triamil
  Remo, Colombia



• Tricolam
  Farmasierra, Spain



• Triconidazol
  ABL, Peru



• Trimonase
  Mipharm, Italy



• Trinigyn
  Grünenthal, Mexico



• Troxxil
  Chile, Chile; Ivax, Peru

International Drug Name Search

Glossary

BAN	British Approved Name
DCF	Dénomination Commune Française
DCIT	Denominazione Comune Italiana
IS	Inofficial Synonym
JAN	Japanese Accepted Name
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.